WinTopMost is the most expensive software in its category that cost $65 for a single license. NoClose is free and has been successfully tested on Windows 7 SP1 32-bit without problems. It is possible to change the default hotkeys from the Settings by right clicking on the NoClose icon at the notification area and select Settings.
From what I’ve noticed, NoClose only disables the Close button located at the top right of the window while other methods such as Alt+F4 still works. Make sure that NoClose is running or else it won’t work. If you want the changes to be permanent, press Ctrl+2 instead to add the program to the rules. To disable the close button on a selected window, press Ctrl+1 to temporarily enable or disable it. If you’ve heard of DonationCoder, Skrommel came out with a simple and easy to use portable tool called NoClose where it simply disables the Close (X) button located at the top right of the window.
